Self esteem

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Self-esteem is a combination of psychological factors that can include confidence, assertiveness, self-respect, strong bonds to and/or the respect of other people. Sometimes it includes conceit, arrogance and an attitude of superiority.But what does gender have to do with self-esteem? Gender, whether you are male or female, is a biological circumstance. However, when it comes to self-esteem, not only the biological but the sociological aspects are important. Males, however, tend to have higher self-esteem than women due to the emphasis placed on a women's appearance by society (Cooke 1).

Appearance can raise or lower a persons self-esteem. Many societies will place a relative value and thus position in society on how people look. For example, in medieval Europe and ancient China laws dictated what clothing styles and materials people could wear according to their social class (Tafinger). Today, clothing, hairstyles, weight, facial features, etc., are elements in many peoples self-esteem. Sometimes people will even go into debt to have plastic surgery done on their faces and bodies to fit better the ideal that they think society deems of value. For example, in America the ideal appearance of a woman is to be physically fit, stylish, and apparently young.

Until the 170's a woman's life was to get married and have children. She was happy and comfortable with this way of life; she did not worry about appearance. However, as women began to work they competed for acceptance and respectand appearance counted.Since those times the number of women unhappy with their appearance has drastically increased, while the number of men has stayed virtually the same according to the study done by Alan Feingold, PhD. (Billie and Chatterjee).

Dr. Emily Hancock, a psychologist in Berkeley California has discovered through various studies that self-esteem in girls peaked at the age of , and then began to plummet. She found out that girls tend to lose their strength, independence, and spirit and become wrapped up with the issue of how they look. As a result of this she believes they fall into depression, have eating disorders and severely abuse drugs.

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The Commonwealth Fund survey in 17 of ,586 girls and ,16 boys grades 5 to 1 revealed that by high school age, onlypercent of girls were highly self confident and that older girls had less self-esteem than the younger ones. "In contrast," the fund reported, "older boys were more likely to be highly self confident than younger boys, with more than half of all boys in high school indicating high self-esteem… One quarter (1/4) of the older girls said they did not like themselves, but only fourteen (14) percent of the boys had said they felt that way."

"Girls and young women tend to be more critical of themselves although opportunities for them have never been greater than they are today in the United States"(Brody "Parents").Schools and society- mass medias especially- have been blamed for the decline of self-esteem and rise in health damaging behavior among teen age girls by focusing their attention on superficial issues like make up, hair, clothing and weight,

"The planet of Melrose Place, or the fake world of magazines, television and movies only make up an estimated 5 percent of the world" (Brody "Puberty").The national craze with perfect bodies and the idea that bodies are perfectible heightens the pressure on teenagers and complicates adjustment to their own bodies. The fitness obsession can aggravate adolescent self-consciousness and tends to make teenage girls awfully unhappy.

For many people achieving what is good appearance is self-satisfying. Again people tend to base the decision on what to do and what looks good on a comparison with other people in society. "Self-esteem is to a large extent cultural rather than a biological factor in human behavior… None the less people need self-esteem it gives the sense of self worth and determination to find life worth living" (Taflinger).

Works Cited

Cooke, Kaz. Real Gorgeous The truth about Body & Beauty. New YorkW.W. Norton, 16.

Brody, Jane E. "Parents Can Bolster Girls Fragile Self-Esteem." New York Times 11 Nov. 17 F7.

_____,_____ "Girls and Puberty the crisis Years." New York Times4 Nov. 17F.

Billie, Katherine, and Camille Chatterjee. "The New Gender Gap." Psychology Today 5(18) .

Taflinger, Richard F. PhD. "Me myself and I Self- Esteem and Advertising." May 16.

http//www.wsu.edu8080/~taflinge/esteem.html (8 May 000)

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Sugar Tricks

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Sugar tricks

How much sugar have you consumed today? You would probably answer ¡§one or two pieces of candy', and if you also count the sugar in your coffee or the bottle of Pepsi you just drunk, congratulations --- you are on the right track, but there is still a long way to go. It's true that sugar is present naturally in every food, yet most of it enters our bodies as refined sugar, which is added artificially. According to the reports released by U.S. Senate Select Committee on Nutrition and Human Needs, Americans consume a hundred pounds of refined sugar each year, on average. Though basically, sugar is not a harmful substance, but over-consumption causes tooth decay and obesity, and increases the risk of getting diabetes. As a form of carbohydrates, sugar supplies 11 calories per ounce (or four per gram), but is completely lacking in vitamins, minerals and other nutritive substances.

How can we consume so much sugar without even notice it? It's simply because most of it are present in forms that we are not aware of. Basically we consume sugar from these four different categories of food junk fluid, sugar-loading breakfast, dessert and straight sugar.

Junk fluids --- soft drinks and sodas --- contribute a quarter of our sugar intake from processed food. It's even more significant in children over forty-four percent of refined sugar comes from this ¡§liquid candy' for kids. This has not yet included those ¡§fruit juices' that are actually low in real fruit juice (probably just ten percent or even lower) but high in sugar content. Liquid sugar is powerful in the sense that we need to drink a lot of fluid everyday, and sugar easily enters our bodies in large quantities without us being aware of it.

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Then come breakfast cereals and baked goods. They load our breakfast with tons of sugar --- this is not even unaware, but unknown to many people. More than half of the calories of cereals, muffins, cookies and donuts may come from sugar; even those healthful-sounding granola cereals may have more than fifteen percent sugar content. Commercial-scale cookie baking adds much more sugar to its products than it would otherwise be. It gives us various favors and choices, and at the same time, sugar. Cookies with a creamy, waffle-like layer in between are especially dangerous; there are seven grams of sugar in a single piece of Oreos. Real the label --- the ingredient that comes first is most abundant in the product. Don't forget that sweeteners like corn syrup or high fructose corn syrup are also sugar.

Our ¡§sweet tooth' after meals makes us fall into the trap of sugar again. Desserts like ice-cream, pies, cheesecakes and even ¡§healthy' yogurts are loaded with sugar. In fact, sugar is one of the ¡§all natural' ingredients that many ice-cream manufactures boast about nowadays. But then isn't it yogurt is a very good choice for dessert? Well, it is true that low-fat yogurt has much fewer calories and more nutritive factors than conventional desserts, but it's still high in sugar content; in fact, more than half of the calories are provided by sugar in yogurts. This is especially significant in yogurt drinks, which may contain as many as almost fifty grams of sugar in a 5ml-bottle, which is more than ten teaspoons!

Concentrated with sugar but with no other nutritive value, candy, undoubtedly, is the king of junk food. Chocolate bars also belong to this category. Unlike many European dark chocolates in which cocoa may be the first ingredient, local brands of chocolates like Hershey's or Nestle Crunch are loaded with sugar. There can be as much as forty grams of sugar in one single chocolate bar. However, there is at least one good thing about candies and chocolates --- unlike cereals or ¡§fruit juices', they never try to hide the fact that they are junk food --- you know very well that you are eating tons of sugar when you indulge in them.

Eating is an enjoyment, and there is nothing wrong with our fondness for sweet things. Yet, we ought to know how much sugar we are consuming on foods that do not seem to contain much of it, and the consequences of over-indulgence in sugar.

Note

1. There are 41g of sugar in a can of Pepsi cola.

. There are 8g of sugar in a 6oz bottle of Yoplait Custard style yogurt, which supplies

11 calories out of its 10 total calories.

. There are 46g of sugar in a 5ml-bottle of Yoplait yogurt drink.

4. By standard measurement, a teaspoonful of sugar is 4g.

5. There are 40g of sugar in a Musketeer chocolate bar.

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Wuthering Heights

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Peter Samfhel

ENWR 106

Professor Eisner

4//0

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Documented Essay

Wuthering Heights, a story that would not usually be read by a person of my interests, definitely has its ways of drawing you away from the book at the same time bringing you deeply in.Pretty ironic I would say, but the perspective very much makes sense. Every story, every movie, every anything has their pros and cons, but my opinion of Wuthering Heights has a strange way of separating those factors.

Referring to my first statement, when I say a person of my interests, I mean to say that a person like me does not get too excited about love stories or any story that takes a long time to get a point across focusing too much on detail rather the readers attention span. As a matter of fact, thats if this was even a love story.But It must be, besides all the hate, vengeance and cruelty, because all those feelings were because of love, and if this is just some twisted love triangle, Jerry Springer has nothing on it. Though talking about the type of person I am may sound irrelevant, there is a connection with this review.How can you accept a review from someone if you dont know what type of person the reviewer is?The reviewer may be nothing like you, so you cannot take his or her opinion into consideration. Saying this, if you are the type of person a reviewer is, read on and take their opinion into consideration and if you are not, you can do two things, either throw away the review or you can just read on anyway out of curiosity for kicks.

This is a strange book.It is not without evidences of considerable powerbut, as a whole, it is wild, confused;disjointed, and improbable;and the people who make up the drama, which is tragic enough in its consequences, are savages ruder than those who live before the days of Homer. (Examiner 85). Great way to start off a review.It gives a big bang and draws me in immediately, but its a shame that I cant take this opinion into consideration.As said, I dont know this examiner, who he/she is, nor have I read any of their reviews on other books that Ive read. This is the first review that I read from them so to take their perspective maybe appealing by the way it started out, it would be blind.

To compare it with the movie buff that I am, I always take a review into consideration before I see a movie.Now, I have never met the reviewers of whom I take their word for, but I definitely have heard enough to make my judgment. Their judgments were correct, right on the money, how I felt or thought about a movie was the same as the reviewer I took into consideration so I stay with the same reviewer because I know we think alike and are attracted to similar types of movies. There are a lot of old timer reviewers who bash on movies that I love.Obviously we dont have the same interests, so why would I even listen to them.

One of the big gripes I have with these reviews has to be that they drag just like the novel itself. Reading the reviews left me in question just as the book did after reading it.Its a lot like the reviews in modern day, many of them dont give a straight answer. Again, the getting to the point aspect of writing about something is crucial for my types.The majority of a review is talking about the novel and going into detail.Why do they do this?When reading a review, it should state three things; quick general idea of the story, was it good or bad and why.You can plead your case without dissecting the book.

To all such Wuthering Heights must appear a rude and strange production. (Editor's Preface to the New Edition of Wuthering Heights (1850) 1).Must?Where are you going with that.And if it is a rude and strange production, is it a good thing?They start out like this, and then get into detail talking about the novel.This shouldn't be the point of a review.

A review should be taken seriously only when you know of the reviewer.Personally, the best reviewers that I have are friends who see or read something that I haven't yet, and they will give me a great review because they are like me.The other point is that reviews should give a straight answer, not just talking about a story, but giving an honest opinion.Many of the reviews that I have read for Wuthering Heights had similar approaches and similar endings leaving me with a question.So was it a good thing or bad thing? Did you like it or not?That's what I want to know, and that is the reason why I would read a novel.If I take your word for it, then I will read it and figure out what it is all about.

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Character Development

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"Biff is two years older than his brother, Happy, well built, but in these days bears a worn air and seems less self-assured." (8, Stage Notes) Biff is a large man, rugged and athletic. He enjoys working outdoors, as is shown by his many farm jobs. Biff is happy outdoors, but he feels that he is wasting his life, and that he should be choosing a career instead of working on a farm.

"Biff, in his high school sweater, enters carrying suitcase. Happy carries Biff's shoulder guards, gold helmet, and football pants." (65, Stage Notes) Biff used to be a promising athlete, and this is how he is remembered by Willy in his flashbacks. This is Biff before he lost faith in his father and lost direction in his life.

"[feeling Biff's muscles] You're comin' home this afternoon captain of the All-Scholastic Championship Team of the City of New York." (67, Willy) Biff's athleticism and physical strength are very important to Willy. The Loman men are all big, masculine men, and physical attributes are vital to them.

Emotional Responses

Custom Essays on Character Development

"What the hell is the matter with him?" (, Biff) Biff responds to every situation the same way his father does; with anger. He is angered very easily as well, even the most minor disturbance is enough to set him off.

"No, Biff. You can't stay here and fight all the time." (41, Linda) Biff and his father constantly fight, and because they are both easily angered, it doesn't take much to start a fight between the two.

"You saw it. The mice didn't bring it into the cellar! What is this supposed to do, make a hero out of you? This supposed to make me sorry for you?" (104, Biff) Biff is angry at his father after finding the rubber hose in the cellar. His confrontation with his father at the end of the play brings forth all of the events which have caused him to lose faith in his father and give up on life.

Mental Ability

"You'll give him the answers!" (6, Willy) Biff is a great athlete, but his poor academic abilities threaten to stop him from graduating. Willy expects Bernard to give Biff the answers so he can pass.

"He never trained himself for anything." (71, Bernard) Biff spent his youth training himself to be an athlete, and once he didn't graduate from high school there was nothing for him to do. He gave up on life and never attempted to graduate afterwards.

"Birnbaum refused absolutely. I begged him, Pop, but he won't give me those points." (, Biff) Biff believes that it is the teacher's fault that he flunked his class, and that it is the teacher's responsibility to give him the points he needs to pass, rather than him have to earn them.

Telling Actions

"Well, I borrowed it form the locker room." (17, Biff) Biff has had a problem with theft ever since his youth. Willy has done nothing to really discourage his problem, actually going so far as to be proud of his son's theft.

"I was all alone in the waiting-room. I don't know what came over me, Hap. The next thing I know I'm in his officepaneled walls, everything. I can't explain it. IHap, I took his fountain pen." (81, Biff) Biff's theft has become so habitual he steals things for absolutely no reason. He steals simply to steal, and it is becoming bad enough that it has cost him several jobs.

"All right, we had it out, I'm going and I'm not writing any more." (10, Biff) Biff has decided that the best thing for himself and his father would be for him to leave and not bother Willy anymore. His father becomes worse when he comes to town, so in the interest of his father he decides to stay away.

Emotional Development

"No, I'm mixed up very bad. Maybe I oughta get married. Maybe I oughta get stuck into something. Maybe that's my trouble. I'm like a boy." (11, Biff) At the beginning of the play Biff is still a very immature, confused, angry man. His life has no direction and he argues with his father constantly.

"You fake! You phony little fake! You fake!" (5, Biff) At the age of seventeen Biff's trust in his father is shattered when he finds out that his father was having an affair. This caused him to give up trying at everything, he gave up on college, on football, on his entire life.

"Pop, I'm nothing! I'm nothing, Pop. Can't you understand that? There's no spite in it any more. I'm just what I am, that's all." (106, Biff) Biff lets out all of the emotion he has been holding back for all these years and lets his father know how he truly feels. After this final confrontation, Biff has said all he has to say, he's finished arguing with his father.

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Neighbors

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Raymond Carver was born in Oregon, and he was a writer and poet. When Carver died in 188 at the age of fifty, he was acclaimed as the greatest influence on the American short story. At the age of nineteen, he married his high-school girlfriend, the sixteen-year-old Maryann Burk, who was pregnant but later had a second marriage. He did some blue-collar jobs, and he finally became a teacher. Most of his stories come from his own life experiences. Carver, in Where Im Calling From, has a tendency to use the first person narrative. Although ¡§Neighbors' is taken from this work, Carver uses the third person narrative to write it. Employing his minimalist style, Carver's ¡§Neighbors' can be considered as an argument about human character that is uncivilized and irrational when unchecked.

Carver uses six scenes to describe the Miller's weird behavior after they are asked to care for their neighbor's apartment. Each scene becomes more odd and unreal. The key represents as an entry to a free and imaginative world without anybody censoring them. The Millers behave oddly there because their curiosity is uncontrolled. People show their real character when they are utterly alone. Like the Millers, people are always jealous of their sibling's, friend's or neighbor's success and want to be successful like they are. ¡§Well, I wish it was us'(70), says Bill Miller, showing his jealousy of his neighbors the Stones, who seem to have a successful life. As a result, when Bill has a chance to get into the Stone's apartment, he wants to feel what it is like to be stone. ¡§He looked at himself in the mirror and then closed his eyes and then looked again' (70). This sentence shows Bill imagining he is Jim Stone. Taking the pills, which belong to Harriet Stone into his pocket and having two drinks show how Bill imitates Jim Stone. Although his behavior can be explained as stealing, his theft serves little purpose except to weird his behavior becomes when unchecked.

Besides imitating Stone, Bill Miller feels excited and successful after staying at the Stone's apartment. As a result, he likes to make love to his wife after he stays there. Carver never mentions Miller's sex life before Bill Miller has the key to go to the Stone's apartment. When he returns, Bill Miller says, ¡§ 'Let's go to bed, honey,' he said' (71). The next day he asks her wife again to go to bed with him. ¡§ 'Now?' she laughed. 'What's gotten into you' ' (71)? It is obvious Arlene feels surprised that her husband wants to have sex often after he feeds the cat. Bill does weirder thing in the Stone's apartment. It is normal for people in a neighbor's house to scan the house or pay attention to what kind of furniture the neighbor has. However, Bill strangely examines everything in Stone's apartment. Taking two bites of cheddar cheese and chewing on an apple also show he wants to consume a part of the Stone's life. Furthermore, stepping into Harriet Stone's panties and brassiere shows how irrational and uncivilized Bill Miller has become. Carver writes about this scene to increase the level of Bill Miller's odd behavior. Not only does Bill Miller enjoy the world in Stone's apartment, but also does his wife, Arlene.

Arlene Miller also shares her husband's odd behavior and stays at the Stone's apartment for a long time, but she forgets to feed the cat. The main purpose of going there is to feed the cat. The reason she stays there for such a long time is obviously to do something as weird as her husband. The first sign of her peculiar behavior is shown in the sentence, ¡§He noticed white lint clinging to the back of her sweater, and the color was high in her cheeks'(7). Arlene says,¡§ I found some pictures' (7). This proves Arlene also tries on the Stone's clothes, uses some cosmetics, and searches the apartment. ¡§ 'It's funny,' she said. 'You know-to go in someone's place like that.' '(7). This observation brings out the main idea of this short story The Millers act uncivilized irrationally when unchecked. Carver wants to bring out that their darker side is a part of their basic characteristics. At the end, the locked door represents an end for the story, but leaves the reader to imagine what weird behavior could be performed by the Millers.

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Carver's story ¡§Neighbors' sets up an argument to show that human character is uncivilized and irrational when unchecked and that uncivilized and irrational behavior is a basic characteristic. In ¡§Neighbors,' the Millers act weirdly not only from curiosity but also because without the censure of society's eyes, humans are capable of acting in unknown, mysterious ways.

Please note that this sample paper on Neighbors is for your review only. In order to eliminate any of the plagiarism issues, it is highly recommended that you do not use it for you own writing purposes. In case you experience difficulties with writing a well structured and accurately composed paper on Neighbors, we are here to assist you.Your persuasive essay on Neighbors will be written from scratch, so you do not have to worry about its originality.

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Living & learning at HFLS

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Living and Learning at Hangzhou Foreign Language School

Good morning, my dear classmates and dear teachers

As soon as I received this topic, I felt that I had a lot to say. Yes, there are so many unforgettable memories that I dont know how to begin. Up to this point of my short-lived life, Living and learning at HFLS must be the most precious treasure in my life.

Three years ago, everyone thought I was lucky enough to enter such a fantastic school, and so did I. I'm sure that they still have this conception now, but I don't share this same thought. They admired me because of the fame of the school. The sentences I heard most were ¡°HFLS specializes in teaching English.¡± ¡°Studying in the school means one of your legs has already entered the gate of a university.¡± ¡­. I didn't change my mind until I started living and learning at HFLS. I found the reason our school was good was not because of its fame, but rather due to the lovely students and teachers.

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I remember quite clearly when I first came into the dormitory, my roommates said ¡°Hello¡± to me with warm smiles. And then we spent the whole noon talking about ourselves although we hadn't met each other before. And I remember Kate was sitting on her bed, reading a book by the name of ¡°Outlaws of the Marsh¡±; Phyllis was lying on her bed, talking happily about her favorite cartoon¡­. I fell in love with these adorable girls at first sight! The longer we live together, the deeper affection we have. I found that all the classmates were pure, clever and beautiful!

Two months ago, Kate asked me what the most unforgettable thing is in my junior life. I answered without thinking ¡°mini-play!¡± then both she and eylie laughed. ¡°We had the same answer!¡± they told me. Mini-play, as a line through out my junior life from the very beginning to the end, brings me a lot of excitement and passion! From Mini-play, I realized that I liked singing, acting, and I really enjoyed the feeling when I was standing on the stage! Mini-play gave me confidence, and it taught me to be brave. But what I really appreciated was that it helped me open a door of making friends--Eric always makes faces though he's a tall handsome boy; Leo is docile though he never corrects his mistakes; Frank is outgoing though sometimes he's a little naughty; and the two girls, Jenny and Olive are also lovely and kind¡­. Although there were some arguments between us, we still regard each other as good friends. Because we all know that a friend is someone who brightens your day with a smile, a warm hello, or gentle words from the heart; a friend is a precious gift to be cherished and nurtured. A friend is a treasure beyond worth.

Teachers, have also been an important part of my junior life.They have had a positive influence on me. Actually, I have a dream of being a teacher of HFLS because we all agree that the teachers (especially the English teachers) in our school are the prettiest! Of course, this is not the emphasis. I like the teachers since they're kind, friendly, gentle, patient and young in their hearts--It seems that sweet smile will not disappear from Miss. Pan's face; sharp eye-contact will not fade through Ms. Tu's glasses¡­. Miss.Xie is mature and graceful; Ms.Xu is frank and straightforward; Mr.Cai is careful and rigorous¡­. Every teacher has his own charm of personality. Eylie always says ¡° The teachers in our school are usually the people who love teaching a lot. According to their ability, they can get a better job, which earns much more money than being a teacher! ¡± Living and learning with such lovely teachers, I feel deeply warm in my heart. So here I'll end my speech with a poem written by Linda

Ive nothing else to offer

So, to you its love Ill send

Its nothing that I borrowed

And its nothing that Id lend

It has no dollar value

And it cant be overused

It isn't fragile, so it can't break

Though, often it's abused

I've given it to others

But each time it's unique

Its meaning's always different

It depends on what you seek

It's something you can store away

To feel when you're in need

But never is it on display

Its beauty can't be seen

I'm giving it ¡°no strings attached¡±

No costly warranty

This love that I am sending

Has a lifetime guarantee. It is a speech for the Art.Cahill Speech Contest in our school. Though I was failed in the contest, I learnt more in trying.

Please note that this sample paper on living & learning at HFLS is for your review only. In order to eliminate any of the plagiarism issues, it is highly recommended that you do not use it for you own writing purposes. In case you experience difficulties with writing a well structured and accurately composed paper on living & learning at HFLS, we are here to assist you.Your cheap research paperson living & learning at HFLS will be written from scratch, so you do not have to worry about its originality.

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Drugs

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Drug Dependency

Introduction

We hear a lot about what happens after people get hooked on drugs. In New South Wales experts are meeting this week to tackle Australias drug problems. But why do people become dependant on drugs? Why is it so hard to get off them?

SCRIPT

Help with essay on drugs

Have you ever had those chocolate cravings, when you need to have some? You feel like a chocoholic. You feel dependent on it.

We can be dependent on a whole range of things. We find that people might be dependent on chocolate bars, on jewellery, chocolate cake, cars and some people are dependent on work. When you look at the difficulties some people might have by being dependent on work, theyre very similar to problems some people might have who are dependent on drugs.

Steve Alsop - Drug & Alcohol Researcher

Often when dependency involves drugs it becomes serious.

When a drug enters the body it influences how the cells in the body behave. Different drugs have different effects. The cells in the body have to change to cope with the drug, and if a drug is used more and more, some cells may never change back completely. The changed cells send out signals that they need to have more of the drug.

They need the drug in the system to function normally, as the body has become used to having the drug. When the drugs not taken, then withdrawal symptoms set in and some of these include craving for the drug.

Steve Alsop - Drug & Alcohol Researcher

Withdrawal symptoms can range from being bad tempered, getting headaches to full on shaking and vomitting. The only way to feel normal is to have the drug.

Some drugs influence our bodys cells more than others, as they are more addictive. These drugs are heroin, alcohol and nicotine, which is found in cigarettes.

If a drug is used more often, or if its stronger, dependency can increase.

Users can also become attached to the friendships and the routines they follow while taking drugs. .

If I were to give up drinking for example, I might not just miss the alcohol I might miss the relationships and going to the pub with my mates. So youd actually be asking the person to change the drug use and the lifestyle that goes with the drug use.

Steve Alsop - Drug & Alcohol Researcher

There are lots of risks involved with taking drugs. If youre hooked it means youre using them more so the risks increase.

Alcohol

destroys brain cells and damages the liver

Smoking

can cause lung cancer and heart disease

Injecting Heroin

can spread HIV and Hepatitis C into the blood.

The drug itself carries a risk in relation to the purity of the drug. Other risks include how you take you take it into the body, whether you drink it, smoke it, or inject it. Quite clearly the more often you take some of these drugs, the greater the risk.

Steve Alsop - Drug & Alcohol Researcher

KICKING THE HABIT

Some people go cold turkey, stopping suddenly. Others find that too hard. They may use medical drugs to help get rid if their craving.

Not all cures work for everybody. Most experts agree that there need to be lots of different treatments available to help people kick the habit.

http//www.abc.net.au/btn/scripts/1/18may-7.htm

Dr Robert Vandenberg is investigating the molecular pharmacology of neurotransmitter transporters in the central nervous system. The research group uses a combination of molecular biological and electrophysiological techniques to investigate the molecular basis for the action of endogenous modulators and also novel drugs acting on neurotransmitter transporters.

Glutamate is the predominant excitatory neurotransmitter in the brain and dysfunction of glutamate transporters has been implicated in the pathogenesis of neurological disorders such as motor neurone disease, epilpesy and also ischaemia following a stroke. Our work focuses on understanding the basic mechanisms of transport and how this may influence neurotransmission in normal and pathological situations.

Glycine is both an inhibitory and excitatory neurotransmitter and we are investigating the role of glycine transporters in controlling glycine concentrations in the CNS. Glycine transporters may be useful targets for novel antipyschotic drugs and through a collaborative project with Allelix Neuroscience Inc., we are investigating the mechanism of action of novel glycine transport inhibitors used to treat schizophrenia. This work will provide a better understanding of the potential for manipulation of glycine concentrations as a way treating this debilitating neurological disorder.

Research in the Molecular Neuropharmacology lab is supported by two project grants from the National Health and Medical Research Council of Australia.

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