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Drug Dependency
Introduction
We hear a lot about what happens after people get hooked on drugs. In New South Wales experts are meeting this week to tackle Australias drug problems. But why do people become dependant on drugs? Why is it so hard to get off them?
SCRIPT
Help with essay on drugs
Have you ever had those chocolate cravings, when you need to have some? You feel like a chocoholic. You feel dependent on it.
We can be dependent on a whole range of things. We find that people might be dependent on chocolate bars, on jewellery, chocolate cake, cars and some people are dependent on work. When you look at the difficulties some people might have by being dependent on work, theyre very similar to problems some people might have who are dependent on drugs.
Steve Alsop - Drug & Alcohol Researcher
Often when dependency involves drugs it becomes serious.
When a drug enters the body it influences how the cells in the body behave. Different drugs have different effects. The cells in the body have to change to cope with the drug, and if a drug is used more and more, some cells may never change back completely. The changed cells send out signals that they need to have more of the drug.
They need the drug in the system to function normally, as the body has become used to having the drug. When the drugs not taken, then withdrawal symptoms set in and some of these include craving for the drug.
Steve Alsop - Drug & Alcohol Researcher
Withdrawal symptoms can range from being bad tempered, getting headaches to full on shaking and vomitting. The only way to feel normal is to have the drug.
Some drugs influence our bodys cells more than others, as they are more addictive. These drugs are heroin, alcohol and nicotine, which is found in cigarettes.
If a drug is used more often, or if its stronger, dependency can increase.
Users can also become attached to the friendships and the routines they follow while taking drugs. .
If I were to give up drinking for example, I might not just miss the alcohol I might miss the relationships and going to the pub with my mates. So youd actually be asking the person to change the drug use and the lifestyle that goes with the drug use.
Steve Alsop - Drug & Alcohol Researcher
There are lots of risks involved with taking drugs. If youre hooked it means youre using them more so the risks increase.
Alcohol
destroys brain cells and damages the liver
Smoking
can cause lung cancer and heart disease
Injecting Heroin
can spread HIV and Hepatitis C into the blood.
The drug itself carries a risk in relation to the purity of the drug. Other risks include how you take you take it into the body, whether you drink it, smoke it, or inject it. Quite clearly the more often you take some of these drugs, the greater the risk.
Steve Alsop - Drug & Alcohol Researcher
KICKING THE HABIT
Some people go cold turkey, stopping suddenly. Others find that too hard. They may use medical drugs to help get rid if their craving.
Not all cures work for everybody. Most experts agree that there need to be lots of different treatments available to help people kick the habit.
http//www.abc.net.au/btn/scripts/1/18may-7.htm
Dr Robert Vandenberg is investigating the molecular pharmacology of neurotransmitter transporters in the central nervous system. The research group uses a combination of molecular biological and electrophysiological techniques to investigate the molecular basis for the action of endogenous modulators and also novel drugs acting on neurotransmitter transporters.
Glutamate is the predominant excitatory neurotransmitter in the brain and dysfunction of glutamate transporters has been implicated in the pathogenesis of neurological disorders such as motor neurone disease, epilpesy and also ischaemia following a stroke. Our work focuses on understanding the basic mechanisms of transport and how this may influence neurotransmission in normal and pathological situations.
Glycine is both an inhibitory and excitatory neurotransmitter and we are investigating the role of glycine transporters in controlling glycine concentrations in the CNS. Glycine transporters may be useful targets for novel antipyschotic drugs and through a collaborative project with Allelix Neuroscience Inc., we are investigating the mechanism of action of novel glycine transport inhibitors used to treat schizophrenia. This work will provide a better understanding of the potential for manipulation of glycine concentrations as a way treating this debilitating neurological disorder.
Research in the Molecular Neuropharmacology lab is supported by two project grants from the National Health and Medical Research Council of Australia.
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